Dexamethasone sodium phosphate is a kind of pharmaceutical raw materials and intermediates, and its chemical formula is C22H28FNa2O8P, CAS No is 2392-39-4. Dexamethasone sodium phosphate is a white to off-white crystalline powder.
Dexamethasone sodium phosphate is a kind of adrenal corticosteroids. It has anti-inflammatory, anti-allergic, anti-rheumatic, immune inhibition. It is mainly used for allergic and autoimmune inflammatory diseases. Used for connective tissue disease, active rheumatism, rheumatoid arthritis, lupus, severe bronchial asthma, severe dermatitis, ulcerative colitis, acute leukemia, but also for certain serious infections and poisoning, malignant lymphoma comprehensive treatment.
Dexamethasone sodium phosphate is a kind of glucocorticoid drugs. Replacement therapy in the application of physiological doses, no significant adverse reactions; adverse reactions occurred in the application of pharmacological doses, but with medication, dosage, drug type, usage and route of administration and other closely related. Common adverse reactions following categories:
Long-term use can cause the following side effects: Iatrogenic Cushing syndrome face and body, weight gain, lower extremity edema, purple pattern, easy bleeding tendency, wound healing, acne, menstrual disorders, brachial or avascular necrosis , osteoporosis and fractures (including vertebral compression fractures, pathologic fracture of long), muscle weakness, muscle atrophy, hypokalemia syndrome, gastrointestinal irritation (nausea, vomiting), pancreatitis, peptic ulcer or perforation, Child growth was inhibited, glaucoma, cataracts, benign intracranial hypertension syndrome, impaired glucose tolerance and diabetes increase.
Patients with psychiatric symptoms may occur: euphoria, excitement, delirium, anxiety, disorientation, also showed inhibition. By the high incidence of psychiatric symptoms and chronic wasting disease and those who had previously mentally normal.
Concurrent infection is adrenocorticotropic hormone major adverse reaction. In fungi, tuberculosis, Staphylococcus aureus, Proteus mirabilis, Pseudomonas aeruginosa, and various herpes viruses based.
Glucocorticoid withdrawal syndrome: Sometimes patients after discontinuation of dizziness, fainting tendency, abdominal or back pain, low fever, loss of appetite, nausea, vomiting, muscle or joint pain, headache, fatigue, weakness, after careful examination to rule out adrenal insufficiency and the original disease resurgence, could be considered for glucocorticoid dependence syndrome.
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