We can provide you Indazole-3-carboxylic acid

 

With the CAS registry number 4498-67-3, the IUPAC name of Indazole-3-carboxylic acid is 1H-indazole-3-carboxylic acid. Indazole-3-carboxylic acid is used in organic synthesis. For example: it can react with 1,4-dimethyl-[1,4]diazepan-6-ylamine to get 1H-indazole-3-carboxylic acid.This reaction needs reagent 1-ethyl-3-3-(dimethylamino)propyl carbodiimide hydrochloride and solvent CH2Cl2 at ambient temperature. The reaction time is 5 hours. The yield is 21%.

You can buy Indazole-3-carboxylic acid(CAS NO:4498-67-3) in our guidechem, now I will show some suppliers of Indazole-3-carboxylic acid in guidechem.

1.Hangzhou Dayangchem Co., Ltd.
Updatetime:Dec 31 2013
DetailDesc:Indazole-3-carboxylic acid
Tel:86-571-88938639
Address:B/2601 Fuli Building, 328# WenEr Rd. Hangzhou City 310012 China

2.Capot Chemical Co., Ltd.
Updatetime:Dec 31 2013
Purity:98% Min. Order:1/Kilogram Supply Ability:up to kgs Month/Kilogram
DetailDesc:162.15,C8H6N2O2
Tel:86-571-85586718
Address:Joinhands Science Park, No.4028,Nanhuan Road,

3.Wuhan Haizheng Industry & Trade Development Co. Ltd
Indazole-3-carboxylic acid(CAS NO:4498-67-3)
Updatetime:Dec 23 2013
Purity:98% Min. Order:10/Gram Supply Ability:1000 Year/Metric Ton
DetailDesc:EINECS: 224-794-5 Molecular Formula: C8H6N2O2 CAS Registry Number: 4498-67-3
Tel:86-27-88660577
Address:27th FL.shuian international masion Bldg.1,Heping Ave.wuhan city

4.Aopharm
Indazole-3-carboxylic acid
Updatetime:Dec 31 2013
Purity:99%
DetailDesc:yellow crystal
Tel:86-311-66600578
Address:C-2103 Wonder Business Square, 15 Yuhua West Rd.

5.Atomax Chemicals Co.,Ltd
Updatetime:Dec 11 2013
Purity:95%+ Min. Order:mg/g/Gram Supply Ability:kg/T Month/Kilogram
DetailDesc:We are a leading global supplier and manufacturer of chiral chemicals, amino acids, aromatic and pyridine halogens, natural extracts and pharmaceutical raw materials. Those chemicals are widely used in the pharmaceutical and fine chemical industries and in research laboratories.
Tel:86-755-33239182
Address:Huiji302 Hutingju Sanwei Xixiang SHENZHEN 518126, China

6.China Huanyu Chemical Industrial Co.,Ltd
Updatetime:Dec 31 2013
DetailDesc:Indazole-3-carboxylic acid
Tel:86-310-6034055
Address:Maoyi Road,Hanshan District,Handan

7.Ningbo Sialon Chem Co., Ltd.
Updatetime:Dec 30 2013
Purity:0.99 Min. Order:10 Kilogram/Kilogram Supply Ability:100Kilogram Month/Metric Ton
DetailDesc:White crystal powder
Tel:+86-574-28809708
Address:Changle Village, Gaoqiao Town, Yinzhou District, Ningbo City, Zhejang Province, China(CN) .

8.Shijiazhuang Kaizheng Trading Co.,Ltd
Indazole-3-carboxylic Acid
Updatetime:Dec 30 2013
DetailDesc: best packing , shipping and will offer you our most competitive price . keep you good quality . hope you can come back to us . welcome you inquiry to us .
Tel:86-311-67503938
Address:1-1-818 lemo building,No.18 north of Pingan street,Qiaodong district,Shiajiazhuang

9.Boc Sciences
Indazole-3-carboxylic acid
Updatetime:Dec 20 2013
DetailDesc:Indazole-3-carboxylic acid
Tel:1-631-5046093
Address:45-16 Ramsey Road Shirley, NY 11967, USA

10.Shijiazhuang Sdyano Fine Chemical Co., Ltd
Indazole-3-carboxylic acid
Updatetime:Dec 31 2013
DetailDesc:Shijiazhuang Sdyano Fine Chemical Co., Ltd. is a company specializing in pharmaceutical intermediates, liquid crystal intermediates, PDLC LCD, OLED LCD, such as fine chemicals R & D, production and sales of integrated chemical enterprise modernization.
Tel:86-311-89830448
Address:Room 37-2-2501, Yiyuan Dong Gang Jianshe Nan Stree

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You can trade D(+)-Malic acid in guidechem

 

D(+)-Malic acid is an organic compound with the formula HO2CCH2CHOHCO2H. It is a dicarboxylic acid that is made by all living organisms, contributes to the pleasantly sour taste of fruits, and is used as a food additive. Malic acid has two stereoisomeric forms (L- and D-enantiomers), though only the L-isomer exists naturally. The salts and esters of malic acid are known as malates. The malate anion is an intermediate in the citric acid cycle.

D(+)-Malic acid(CAS NO: 636-61-3) is a kind of white crystals or white crystalline powder, soluble in water, alcohol and other organic solvent. Its aqueous solution is acidic. It is an important four-carbon atoms chiral pool. It is mainly used in many fields including chiral pharmaceuticals, chiral additives and chiral auxiliaries. It is used as chiral pool of chiral synthesis in pharmaceutical and food industries.

1.Hangzhou Dayangchem Co., Ltd.
D-(+)-Malic acid(CAS NO: 636-61-3)
Updatetime:Dec 30 2013
DetailDesc:D-(+)-Malic acid
Tel:86-571-88938639
Address:B/2601 Fuli Building, 328# WenEr Rd. Hangzhou City 310012 China Hangzhou Dayangchem Co., Ltd.

2.Shanghai Dell Chemical Co.Ltd
Updatetime:Dec 27 2013
Purity:NLT99% Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton
DetailDesc:Shanghai Dell Chemical Co.Ltd. is specialized in trading and developing active pharmaceutical ingredients, intermediates, API, and custom synthesis according to client’s requirements.
Tel:86-21-51950635
Address:Nianjiabang Rd, Pudong, Shanghai

3.Capot Chemical Co., Ltd.
Updatetime:Dec 27 2013
Purity:98% Min. Order:1/Kilogram Supply Ability:up to kgs Month/Kilogram
DetailDesc:134.09,C4H6O5
Tel:86-571-85586718
Address:Joinhands Science Park, No.4028,Nanhuan Road,

4.Jinan Haohua Industry Co., Ltd.
D(+)-Malic acid
Updatetime:Dec 30 2013
Purity:99 Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton
Tel:0086-531-58773055
Address:No.59 Gongye South RD

5.Changsheng International Chemical Industry Co.Ltd.
Updatetime:Dec 30 2013
Supply Ability:Success
DetailDesc:D-(+)-Malic acid
Tel:86-311-80955068
Address:No 98 Gongnong Street,Shijiazhuang Hebei,China

6.Shanghai Pengteng Fine Chemical Co., Ltd.
Updatetime:Oct 17 2013
DetailDesc:Our company keeps the business tenet of “people first and customer esteemed” and the service principle of “superior quality, reasonable price, good faith”. We insist on the principle of win-win cooperation and would like to create brilliant future hand in hand with you!
Tel:86-15262230-560
Address:No.9, Haikou Road, Huai’an Industiral Park, Jiangsu Province, China

7.Zhangjiagang Specom Biochemical Co.,Ltd
Updatetime:Dec 30 2013
Purity:99% Min. Order:1/Kilogram
DetailDesc: Molecular Formula: HO 2 CCH 2 CH(OH)CO 2 H Molecular Weight: 134.09 Cas No: 636-61-3 Characteristics: White or a kind of white to yellowish crystalline powder, 140 C decompounds, soluble in water, alcohol. Use: D-Malic acid is used in food, pharmaceuticals, chemical and other areas.
Tel:86-512-58992287
Address:Economic Development Zone

8.Nanjing Chemlin Chemical Co., Ltd.
D(+)-Malic acid
Updatetime:Dec 23 2013
Purity:98%
DetailDesc:(R)-(+)-2-Hydroxysuccinic acid, D-(+)-Malic acid, D-Hydroxybutanedioic acid
Tel:86-25-83697070
Address:Rm.902 Longyin Plaza, No. 217 Zhongshan Rd.(N) Nanjing 210009,China

9.Shanghai Hongbang Medical Technology CO., Ltd
D(+)-Malic acid
Updatetime:Dec 24 2013
FOB Price:0 USD/Kilogram Purity:99.0%min Min. Order:1/Kilogram Supply Ability:8 Year/Metric Ton
DetailDesc: Name: D(+)-Malic acid; Molecular Formula: C4H6O5; Molecular Weight: 134.09; CAS Registry Number: 636-61-3 ; EINECS: 211-262-2; Tel:86-136-71516988
Address:Yongde Road369, Minhang District, Shanghai City

Want to learn more information about D(+)-Malic acid, you can access the guidechem.com. Guidechem.com is just a place for you to look for some chemicals. Guidechem provide the most convenient conditions for the international buyers and let these leads benefit all the business people.

Looking for 3-Bromo-5-fluoropyridine

In this article, I will show you a online supply platform where you can buy or sell 3-Bromo-5-fluoropyridine or any other chemicals. Here are the nearly suppliers’ informetion about 3-Bromo-5-fluoropyridine (CAS NO: 407-20-5)in guidechem.

1.AOPHARM
Updatetime:Dec 26 2013
Purity:99%
DetailDesc:Colorless liquid
Tel:86-311-66600578
Address:C-2103 Wonder Business Square, 15 Yuhua West Rd.

2.Hangzhou Dayangchem Co., Ltd.
3-Fluoro-5-bromopyridine (CAS NO: 407-20-5)
Updatetime:Dec 26 2013
DetailDesc:3-Fluoro-5-bromopyridine
Tel:86-571-88938639
Address:B/2601 Fuli Building, 328#WenEr Rd. Hangzhou City 310012 China

3.Capot Chemical Co., Ltd.
Updatetime:Dec 25 2013
Purity:98% Min. Order:1/Kilogram Supply Ability:up to kgs Month/Kilogram
DetailDesc:175.99,C5H3BrFN
Tel:86-571-85586718
Address:Joinhands Science Park, No.4028,Nanhuan Road

4.Jinan Haohua Industry Co., Ltd.
Updatetime:Dec 26 2013
Purity:99 Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton
DetailDesc:Haohua Industry has set up four big production bases and one R&D Center in China. Over the past years, we are engaged in the exporting business, our products have reached far to the USA, Europe, South Asia, Middle East and so on, also our company has established long term.
Tel:0086-531-58773055
Address:No.59 Gongye South RD

5.Andexin industrial Co.,Limited
Updatetime:Dec 26 2013
Min. Order:1/Gram Supply Ability:1 Month/Metric Ton
Tel:86-411-39074598
Address:No.98,Shengli road,,Jinzhou district,
Introduction:Andexin industrial Co.,Limited was established in 2001. Our company is a professional high-tech enterprise located in China northeast, enjoying convenient transportation access, and its products have been issued with ISO 9001:2008. Our products has been exported to more than twenty countries and won good reputation among our old customers.

6.Shanghai UCHEM Inc.
Updatetime:Dec 26 2013
DetailDesc:3-bromo-5-fluoropyridine
Tel:086-021-61555264
Address:4th Floor,Build A,500Jianyun Road,Zhoupu,Pudong,Shanghai

7.China Huanyu Chemical Industrial Co.,Ltd
3-bromo-5-fluoropyridine
Updatetime:Dec 26 2013
DetailDesc:3-bromo-5-fluoropyridine
Tel:86-310-6034055
Address:Maoyi Road,Hanshan District,Handan

8.Hui Chem Company Limited
Updatetime:Dec 23 2013
Purity:98% Min. Order:1/Gram Supply Ability:10 Month/Kilogram
DetailDesc:We could receive custom synthesis according to your requirements from lab scale to commercial scale
Tel:86-21-60542966
Address:Lane 299 Bisheng Rd,Pudong District

9.Boc Sciences
5-Bromo-3-fluoropyridine
Updatetime:Dec 20 2013
DetailDesc:5-Bromo-3-fluoropyridine
Tel:1-631-5046093
Address:45-16 Ramsey Road Shirley, NY 11967, USA

10.Shijiazhuang Sdyano Fine Chemical Co., Ltd
3-Bromo-5-fluoropyridine
Updatetime:Dec 26 2013
Tel:86-311-89830448
Address:Room 37-2-2501, Yiyuan Dong Gang Jianshe Nan Stree
Introduction:Shijiazhuang Sdyano Fine Chemical Co., Ltd. is a company specializing in pharmaceutical intermediates, liquid crystal intermediates, PDLC LCD, OLED LCD, such as fine chemicals R&D, production and sales of integrated chemical enterprise modernization. Our company has three subsidiaries: R & D center, production base and sales. The production quantity can be done from the number of grams.

11.Nanjing Chemlin Chemical Co., Ltd.
3-Bromo-5-fluoropyridine
Updatetime:Dec 23 2013
Purity:98%
DetailDesc:3-Bromo-5-fluoropyridine
Tel:86-25-83697070
Address:Rm.902 Longyin Plaza, No. 217 Zhongshan Rd.(N) Nanjing 210009,China

Want to learn more suipply information about 3-Bromo-5-fluoropyridine or any other chemicals, you can access the guidechem.com. Guidechem.com is just a place for you to look for some chemicals. Guidechem provide the most convenient conditions for the international buyers and let these leads benefit all the business people.

Lastest suppliers’ informetion about Calcitonin salmon

 

Calcitonin is a polypeptide hormone secreted by the parafollicular cells of the thyroid gland in mammals and by the ultimobranchial gland of birds and fish.

Treating osteoporosis (fragile or brittle bones) in certain women who have been past menopause for more than 5 years. It should be used along with adequate calcium and vitamin D intake. It may also be used for other conditions as determined by your doctor.

Calcitonin-salmon spray is a polypeptide hormone. It works by stopping bone loss and increasing the density or strength of bone.

In this article, I will show you a online supply platform where you can buy or sell Calcitonin salmon or any other chemicals. Here are the nearly suppliers’ informetion about Calcitonin salmon (CAS NO: 47931-85-1)in guidechem.

1.AFINE CHEMICALS LIMITED
Updatetime:Dec 26 2013
Min. Order:1/Gram Supply Ability:10 Month/Metric Ton
DetailDesc:Salmon Calcitonin Acetate 47931-85-1
Tel:86-571-85232161
Address:6th Floor, Block C, 7th Building, Xigang Xinjie, Xihu Industrial Park, Sandun Town, Hangzhou, China

2.Hangzhou Dayangchem Co., Ltd.
Calcitonin salmon(CAS NO: 47931-85-1)
Updatetime:Dec 26 2013
DetailDesc:Thyrocalcitonin
Tel:86-571-88938639
Address:B/2601 Fuli Building, 328# WenEr Rd. Hangzhou City 310012 China

3.Shanghai Dell Chemical Co.Ltd
Updatetime:Dec 25 2013
FOB Price:0 USD/Gram Purity:98% Min. Order:10/Gram Supply Ability:100 Month/Kilogram
DetailDesc:Shanghai Dell Chemical Co.Ltd. is specialized in trading and developing active pharmaceutical ingredients, intermediates, API, and custom synthesis according to client’s requirements.
Tel:86-21-51950635
Address:Nianjiabang Rd, Pudong, Shanghai

4.Jinan Haohua Industry Co., Ltd.
Updatetime:Dec 26 2013
Purity:99 Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton
Tel:0086-531-58773055
Address:No.59 Gongye South RD

5.Boc Sciences
Updatetime:Dec 20 2013
DetailDesc:Calcitonin salmon
Tel:1-631-5046093
Address:45-16 Ramsey Road Shirley, NY 11967, USA

6.Hangzhou Huajin Pharmaceutical Co.,Ltd
Salmon Calcitonin
Updatetime:Sep 10 2013
FOB Price:100 USD/Gram Purity:98.0% min Min. Order:10/Gram Supply Ability:1000 Month/Gram
DetailDesc: CAS Number: 47931-85-1 Name: calcitonin salmon
Formula: C145H240N44O48S2 Molecular Weight:3431.85
Tel:86-571-87207232
Address:317 Wantang Road, Xihu District, Hangzhou City, China

7.Mimotopes Biological Technology Co., Ltd.
Salmon Calcitonin
Updatetime:Dec 25 2013
DetailDesc: Product Name calcitonin salmon CasNo. 47931-85-1 Molecular Formula C145H240N44O48S2 Molecular Weight 3431.85 Purity (HPLC) 98.0% Appearance White powder Single Impurity(HPLC) 0.5%max Amino Acid Composition ±10% of theoretical Peptide Content(N%)
Tel:86-510-83583038
Address:Mimotopes (China) company 1699 Huishan Street C5 Area,the first floor Huishan District,Wuxi,Jiangsu Province,P.R Chnia

8.Hangzhou Sage Chemical Co., Ltd.
Salmon Calcitonin
Updatetime:Nov 22 2013
Tel:+86-571-86818502
Address:RM501 Tower A, New Youth Plaza, NO.8 Jia Shan Road, Hangzhou, Zhejiang 310014,
Introduction:Hangzhou Sage Chemical Co., Ltd is a well-established and continuously growing high-tech company, which is speciallized in researching, manufacturing and marketing high quality pharmaceutical, agrochemical and dyestuff intermediates, fluorochemicals, intermediates of high performance materials,etc. Our laboratories and manufacture plants are located in the Zhejiang and Jiangsu. We provide services.

Want to learn more supply information about Calcitonin salmon or any other chemicals, you can access the guidechem.com.

Online supply 2-Chloro-5-iodopyridine

In this article, I will show you a online supply platform where you can buy or sell 2-Chloro-5-iodopyridine or any other chemicals. Here are the nearly suppliers’ informetion about 2-Chloro-5-iodopyridine (CAS NO: 69045-79-0)in guidechem.

1.Shanghai Dell Chemical Co.Ltd
Updatetime:Dec 25 2013
Purity:NLT99% Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton
DetailDesc:Shanghai Dell Chemical Co.Ltd. is specialized in trading and developing active pharmaceutical ingredients, intermediates, API, and custom synthesis according to client’s requirements.
Tel:86-21-51950635
Address:Nianjiabang Rd, Pudong, Shanghai Shanghai Dell Chemical Co.Ltd

2.Capot Chemical Co., Ltd.
2-Chloro-5-iodopyridine(CAS NO: 69045-79-0)
Updatetime:Dec 25 2013
Purity:98% Min. Order:1/Kilogram Supply Ability:up to kgs Month/Kilogram
DetailDesc:239.44,C5H3ClIN
Tel:86-571-85586718
Address:Joinhands Science Park, No.4028,Nanhuan Road,

3.Hangzhou Dayangchem Co., Ltd.
Updatetime:Dec 25 2013
DetailDesc:2-Chloro-5-iodopyridine
Tel:86-571-88938639
Address:B/2601 Fuli Building, 328# WenEr Rd. Hangzhou City 310012 China

4.Wuhan Haizheng Industry & Trade Development Co. Ltd
2-Chloro-5-iodopyridine
Updatetime:Dec 23 2013
Purity:98 Min. Order:100/Gram Supply Ability:100 Month/Metric Ton
DetailDesc: Name: 2-chloro-5-iodopyridine (Related Reference) Molecular Formula: C5H3ClIN CASRegistryNumber: 69045-79-0 Synonyms: 2-chloro-5-iodo-pyridine; 2-chloro-5-iodopyridine 98% 2g; Molecular Structure: This structure is also ava…
Tel:86-27-88660577
Address:27th FL.shuian international masion Bldg.1,Heping Ave.wuhan city

5.Atomax Chemicals Co.,Ltd
2-Chloro-5-iodopyridine
Updatetime:Dec 11 2013
Purity:95%+ Min. Order:mg/g/Gram Supply Ability:kg/T Month/Kilogram
DetailDesc:We are a leading global supplier and manufacturer of chiral chemicals, amino acids, aromatic and pyridine halogens, natural extracts and pharmaceutical raw materials. Those chemicals are widely used in the pharmaceutical and fine chemical industries and in research laboratories.
Tel:86-755-33239182
Address:Huiji302 Hutingju Sanwei Xixiang SHENZHEN 518126, China

6.Jinan Haohua Industry Co., Ltd.
2-Chloro-5-iodopyridine
Updatetime:Dec 25 2013
Purity:99 Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton
DetailDesc:2-chloro-5-iodo-pyridine;2-chloro-5-iodopyridine 98% 2g;2-chloro-5-iodopyrazine;
Tel:0086-531-58773055
Address:No.59 Gongye South RD

7.Shanghai Pengteng Fine Chemical Co., Ltd.
2-Chloro-5-iodopyridine
Updatetime:Oct 17 2013
DetailDesc:Our company keeps the business tenet of “people first and customer esteemed” and the service principle of “superior quality, reasonable price, good faith”. We insist on the principle of win-win cooperation and would like to create brilliant future hand in hand with you!
Tel:86-15262230-560
Address:No.9, Haikou Road, Huai’an Industiral Park, Jiangsu Province, China

8.Changsheng International Chemical Industry Co.Ltd.
2-Chloro-5-iodopyridine
Updatetime:Dec 25 2013
Min. Order:1/Kilogram
DetailDesc: Classification: Pharmaceutical Intermediates Molecular Formula: C5H3ClIN Melting Point: 96-99C Boiling Point: 253.2 C at 760 mmHg Water Solubility: insoluble Flash Point: 106.9 C Purity: 99% Appearance: off-white to yellow-beige crystalline powder HazardClass: IRRITANT Packaging & Delivery Packaging Detail: as requeste.
Tel:86-311-80955068
Address:No 98 Gongnong Street,Shijiazhuang Hebei,China

9.Shenyang Ideal Chemical Product Co.,Ltd
2-Chloro-5-iodopyridine
Updatetime:Dec 25 2013
DetailDesc: Classification: Pharmaceutical Intermediates Molecular Formula: C5H3ClIN Melting Point: 96-99 C Boiling Point: 253.2 C at 760 mmHg Water Solubility: insoluble Flash Point: 106.9 C Purity: 99% Appearance: off-white to yellow-beige crystalline powder HazardClass: IRRITANT Packaging & Delivery Packaging Detail: as requested Delivery Detail: Detailed Description off-white to yellow-beig…
Tel:86-24-31689845
Address::(1-7-4),18-A South No. 2 Road ,Heping District

Want to learn more supply information about 2-Chloro-5-iodopyridine or any other chemicals, you can access the guidechem.com.

Experiment on Pitavastatin calcium

 

1.Chemicals and reagents

Pitavastatin calcium was from Micro Laboratories. HPLC-grade Acetonitrile and methanol was purchased from Merck, India. Highpurity water was prepared using Millipore purification system. Other chemicals and reagents were of AR grade Pitava 1 and Flovas 1mg were obtained commercially.

2.Instrumentation and chromatographic conditions

HPLC analysis was performed on a Shimadzu LC-10ATVP pump, SPD-M10 AVP with PDA detector. Separation was achieved on the phenomenex C18 (250 x 4.60); 5µ particle size column at room temperature with the mobile phase constituted by 0.5% acetic acid: acetonitrile (35:65) at the flow rate of 1 ml/min. The mobile phase was filtered through 0.45µm nylon filter (Millipore, USA) and degassed by sonication prior to use. The detection was performed at 245 nm. The Standard and sample was introduced through an injector valve with a 20 µl, sample loop. Data acquisition was performed using CLASS-VP software by the measurement of peak areas.

3.Preparation of sample solution

Twenty tablets of Pitavastatin Calcium(CAS NO: 147526-32-7) and Flovas containing 1 mg of Pitavastatin calcium were weighed to get the average weight and then powdered. An amount of powder equivalent to 1 mg of Pitavastatin calcium was transferred to a 100 ml volumetric flask with 50 ml mobile phase and shaken for 10 min, followed by making up to volume with mobile phase. This solution was filtered using 0.2 µ membrane filter. From this 1 ml were pipetted out and transferred to 10 ml volumetric flask, 1 ml of internal standard solution (µg/ml) was added to each and made up to the volume to get the concentration of 1 µg/ml of Pitavastatin calcium.

4.Preparation of standard solution

Standard stock solution of pitavastatin calcium(CAS NO: 147526-32-7) and paracetamol (1000 µg/ml) was prepared in mobile phase containing 0.5% Acetic acid: Acetonitrile 35:65 (%, v/v). Working standard solutions for the calibration curve were prepared by dilution of the above stock solution in a range of 1-5 µg/ml with mobile phase. To each dilution a fixed concentration of 1 µg/ml of internal standard paracetamol was added.

5.Method development and choice of internal standard

A variety of mobile phases and internal standards were investigated in the development of an HPLC method suitable for analysis of Pitavastatin Calcium in the tablet formulations. Finally, the condition adopted was 0.5% acetic acid: acetonitrile 35:65 (%, v/v), at the flow rate of 1 ml/min. Paracetamol was selected as the suitable internal standard for this method.

6.Method validation

The method was validated for the parameters like specificity, range and linearity, limit of detection (LOD), limit of quantitation (LOQ), accuracy, and precision based on ICH/CPMP guidelines

Want to learn more information about Pitavastatin calcium, you can access the guidechem.com.

Benzyl Chloroformate used in the amine protection

 

Cbz is another popular carbamate used in the amine protection. It could be easily deprotected under hydrogenation or triethyl silane.Gabriel Amine synthesis is similar to this protection, go figure out the rest of the mechanism.Dimethyl Pyrrole protection is very useful in primary amine protection, especially you could not have active proton in your molecule.

Fmoc has very good stability in acidic condition, and reasonable stability in inorganic base. It could be removed in a couple minutes with piperidine. You can see a very bright blue spot on your TLC solvent front line. Boc is used extensively in amine protection. It is stable under base condition, could be easily get rid of under TFA/CH2Cl2 (1/1). Boc could be reduced to methyl group under LAH to make single methyl substitution.

Benzyl chloroformate(CAS NO: 501-53-1) is the benzyl ester of chloroformic acid. It is also known as benzyl chlorocarbonate and is an oily liquid whose color is anywhere from yellow to colorless. It is also known for its pungent odor. When heated, benzyl chloroformate decomposes into phosgene and if it comes in contact with water it produces toxic, corrosive fumes.

Benzyl chloroformate(CAS NO:501-53-1) is used in organic synthesis for the introduction of the carboxybenzyl (Cbz or Z) protecting group for amines:

Benzyl protection of phenol. The starting material, phenol (1 equiv.), was dissolved into acetone. BnBr (1.3 equiv.), and K2CO3 (15 equiv.) were added into the acetone solution. The resulting mixture was refluxed for 2 hours. After filtered the solid, the filtrate was concentrated, and the residue was separated by a silica gel plug.

Deprotection of benzyl group: The starting material was dissolved into ethanol with Pd on C. The mixture was put on parr shaker with H2 30 psi for 3 hours. The resulting mixture was filtered, and the filtrate was concentrated to afford almost pure product.

Boc protection of amine group: Amine (1equiv.) and Boc2O (1.5 equiv.) were dissolved into methylene chloride with TEA(2 equiv.). The mixture was stirred for 6 hours at room temperature. The resulting mixture was washed with brine, and the organic layer was dried and concentrated. The resulting residue was separated by silica gel column.

Benzyl chlorofomate amine protection: Amine ( 1equiv.) and TEA (2 equiv.) were dissloved into THF. To the solution, benzyl chloroformate was added dropwise. The resulting mixture was stirred for 4 hours. The precipitate was filtered. Ethyl acetate was added into the organic solution. Brine was used to wash the organic layer. The organic layer was dried, concentrated. The resulting residue was separated by silica gel column to afford 90% yield.

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Suppliers of 2-chloropyridine-4-carboxylic acid in December

Product brief

Product Name: 2-Chloroisonicotinic acid
IUPAC Name: 2-chloropyridine-4-carboxylic acid
Molecular Formula: C6H4ClNO2
Molecular Weight: 157.55446
Surface Tension: 61
Density: 1.47 g/cm3
Melting Point: 246 C
Flash Point: 206.4 C
Boiling Point: 417.7 C
CAS Registry Number: 6313-54-8

Supply companies

1.Shanghai Dell Chemical Co.Ltd

2-chloropyridine-4-carboxylic acid
Updatetime:Dec 17 2013
Purity:NLT99% Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton
DetailDesc:Shanghai Dell Chemical Co.Ltd. is specialized in trading and developing active pharmaceutical ingredients, intermediates, API, and custom synthesis according to client’s requirements.
Tel:86-21-51950635
Address:Nianjiabang Rd, Pudong, Shanghai

2.Capot Chemical Co., Ltd.

2-chloropyridine-4-carboxylic acid
Updatetime:Dec 17 2013
Purity:98% Min. Order:1/Kilogram Supply Ability:up to kgs Month/Kilogram
DetailDesc:157.55,C6H4ClNO2
Tel:86-571-85586718
Address:Joinhands Science Park, No.4028,Nanhuan Road

3.Atomax Chemicals Co.,Ltd

2-chloropyridine-4-carboxylic acid
Updatetime:Dec 11 2013
Purity:95%+ Min. Order:mg/g/Gram Supply Ability:kg/T Month/Kilogram
DetailDesc:We are a leading global supplier and manufacturer of chiral chemicals, amino acids, aromatic and pyridine halogens, natural extracts and pharmaceutical raw materials. Those chemicals are widely used in the pharmaceutical and fine chemical industries and in research laboratories.
Tel:86-755-33239182
Address:Huiji302 Hutingju Sanwei Xixiang SHENZHEN 518126, China

4.Andexin industrial Co.,Limited

2-Chloro-4-pyridinecarboxylic acid
Updatetime:Dec 17 2013
Min. Order:1/Gram Supply Ability:1 Month/Metric Ton
Tel:86-411-39074598
Address:No.98,Shengli road,,Jinzhou district,
Introduction:Andexin industrial Co.,Limited was established in 2001. Our company is a professional high-tech enterprise located in China northeast, enjoying convenient transportation access, and its products have been issued with ISO 9001:2008. Our products has been exported to more than twenty countries and won good reputation among our old customers.

5.Jinan Haohua Industry Co., Ltd.

2-chloropyridine-4-carboxylic acid
Updatetime:Dec 17 2013
Purity:99 Min.Order:1/Kilogram Supply Ability:100 Year/Metric Ton
DetailDesc:2-chloropyridine-4-carboxylate;2-chloropyridine-4-carboxylic acid;2-Chloro-4-Pyridine Carboxylic Acid;2-Chloro Isonicotinic Acid;4-Pyridinecarboxylic acid, 2-chloro-;2-chloro-4-pyridinecarboxylic acid;
Tel:0086-531-58773055
Address:No.59 Gongye South RD

6.Hui Chem Company Limited

2-chloropyridine-4-carboxylic acid
Updatetime:Dec 17 2013
Purity:98% Min.Order:1/Gram Supply Ability:10 Month/Kilogram
DetailDesc:We could receive custom synthesis according to your requirements from lab scale to commercial scale
Tel:86-21-60542966
Address:Lane 299 Bisheng Rd,Pudong District

7.Shanghai UCHEM Inc.

2-Chloropyridine-4-carboxylic acid
Updatetime:Dec 17 2013
DetailDesc:2-Chloropyridine-4-carboxylic acid
Tel:086-021-61555264
Address:4th Floor,Build A,500Jianyun Road,Zhoupu,Pudong,Shanghai

8.Changsheng International Chemical Industry Co.Ltd.

2-chloropyridine-4-carboxylic acid
Updatetime:Dec 17 2013
Supply Ability:Success
DetailDesc:2-Chloroisonicotinic acid
Tel:86-311-80955068
Address:No 98 Gongnong Street,Shijiazhuang Hebei,China

9.Nanjing Chemlin Chemical Co., Ltd.

2-chloropyridine-4-carboxylic acid
Updatetime:Dec 09 2013
Purity:97.00%
DetailDesc:intermediates, drug discovery
Tel:86-25-83697070
Address:Rm.902 Longyin Plaza, No. 217 Zhongshan Rd.(N) Nanjing 210009,China

10.Jiangxi RV Pharmaceutical Co,Ltd

2-chloropyridine-4-carboxylic acid
Updatetime:Dec 10 2013
Purity:≥99.0%
DetailDesc: Melocular formula: C6H4ClNO2 Molecular weight: 157.55
Tel:86-186-70101000
Address:Guixi Industrial Park

Here I can only introduce you the 10 suppliers of 2-chloropyridine-4-carboxylic acid in guidechem, if you need more supply information about 2-chloropyridine-4-carboxylic acid , you can access to our guidechem.com. Guidechem.com is just a place for you to look for some chemicals. Guidechem provide the most convenient conditions for the international buyers and let these leads benefit all the business people. Guidechem chemical B2B network provides information on china and global chemical market quotation and relative chemical Information. Guidechem Chemical Network providing the most complete information of the chemical industry.

Some companies supply Boronicacid, B-3-pyridinyl-

Boronicacid, B-3-pyridinyl- is a kind of Light yellow powder, it is mainly used as Boronic acid derivatives and their binding affinities with diols. The Molecular Formula is C5H6BNO2, and Registry Number is 1692-25-7. Guidechem is a B2B network which provide you chemical information online. In this article,I will show you some supply companies of Boronicacid, B-3-pyridinyl- in guidechem. Here are the company information.

Company one :Hangzhou Dayangchem Co., Ltd.

Boronicacid, B-3-pyridinyl-
Updatetime:Dec 17 2013
DetailDesc:Pyridine-3-boronic acid
Tel:86-571-88938639
Address:B/2601 Fuli Building, 328# WenEr Rd. Hangzhou City 310012 China

Company two :Shanghai Dell Chemical Co.Ltd

Boronicacid, B-3-pyridinyl-
Updatetime:Dec 16 2013
Purity:NLT99% Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton
DetailDesc:Shanghai Dell Chemical Co.Ltd. is specialized in trading and developing active pharmaceutical ingredients, intermediates, API, and custom synthesis according to client’s requirements.
Tel:86-21-51950635
Address:Nianjiabang Rd, Pudong, Shanghai

Company three :Capot Chemical Co., Ltd.

Boronicacid, B-3-pyridinyl-
Updatetime:Dec 13 2013
Purity:98% Min. Order:1/Kilogram Supply Ability:up to kgs Month/Kilogram
DetailDesc:122.92,C5H6BNO2
Tel:86-571-85586718
Address:Joinhands Science Park, No.4028,Nanhuan Road

Company four :Rosewell Industry Co., Ltd

Boronicacid, B-3-pyridinyl-
Updatetime:Nov 24 2013
DetailDesc:We are the leading supplier of imaging chemicals, pharmaceutical intermediates, and OLED intermediates.
Tel:86-519-86202821
Address:Qixing building, Mingxin road, Changzhou,Jiangsu,China

Company five :Shanghai Pengteng Fine Chemical Co., Ltd.

Boronicacid, B-3-pyridinyl-
Updatetime:Oct 17 2013
DetailDesc:Our company keeps the business tenet of “people first and customer esteemed” and the service principle of “superior quality, reasonable price, good faith”. We insist on the principle of win-win cooperation and would like to create brilliant future hand in hand with you!
Tel:86-15262230-560
Address:No.9, Haikou Road, Huai’an Industiral Park, Jiangsu Province, China

Company six :Jinan Haohua Industry Co., Ltd.

Boronicacid, B-3-pyridinyl-
Updatetime:Dec 17 2013
Purity:99 Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton
DetailDesc:3-Pyridineboronicacid (7CI,8CI);Boronic acid, 3-pyridinyl- (9CI);(3-Pyridinyl)boronic acid;3-Pyridylboronicacid;Dihydroxy(3-pyridyl)borane;Pyridine-3-boronic acid;
Tel:0086-531-58773055
Address:No.59 Gongye South RD

Company seven :Hui Chem Company Limited

Boronicacid, B-3-pyridinyl-
Updatetime:Dec 16 2013
Purity:98% Min. Order:1/Gram Supply Ability:10 Month/Kilogram
DetailDesc:We could receive custom synthesis according to your requirements from lab scale to commercial scale
Tel:86-21-60542966
Address:Lane 299 Bisheng Rd,Pudong District

Company eight :Zhejiang Kaili Industrial Co., Ltd.

Boronicacid, B-3-pyridinyl-
Updatetime:Oct 31 2013
DetailDesc:Zhejiang Kaili Industrial Co., Ltd. is collect Science, Industrial and Trade together for a comprehensive high-tech entities. We are mainly engaged in the research, development, production and sales of APIs and pharmaceutical intermediates.
Tel:86-571-85241926
Address:Block C&D,12/F,Lantian Business Center,No.18 Moganshan Road,Hangzhou,China

Here I can only introduce you the 7 suppliers of Boronicacid, B-3-pyridinyl- in guidechem, if you need more supply information about Boronicacid, B-3-pyridinyl-, you can access to our guidechem.com.

New supply information about N-BOC-4-Hydroxypiperidine

N-BOC-4-Hydroxypiperidine is a kind of important pharmaceutical intermediates, it is widely used in industry. Guidechem is a B2B network which provide you chemical information online. In this article,I will show you some supply companies of N-BOC-4-Hydroxypiperidine in guidechem. Here are the company information.

Supply company 1 : Struchem Co Ltd

1-BOC-4-HYDROXYPIPERIDINE(CAS NO:109384-19-2)
Updatetime:Dec 12 2013
Purity:95%min Min. Order:1,5,25/Gram Supply Ability:kilograms Day/kilograms
Tel:86-512-63009836
Address:No. 2358 Chang’an Rd, Wujiang City, JiangSu Province, China 215200
Introduction:Based on BetaPharma(Shanghai) Co., Ltd, Struchem Co.,Ltd estabalished on 2010, the company’s business scope covers special chemicals, agro-chemicals, APIs, natural ingredients Commodity Chemicals, intermediates.

Supply company 2: Nanjing Chemlin Chemical Co., Ltd.

Updatetime:Dec 09 2013
Purity:99.1%. Min. Order:1/Gram Supply Ability:10 Month/Kilogram
DetailDesc:CAS No.:109384-19-2；Name:1-BOC-4-HYDROXY-PIPERIDINE;Appearance:White powder;Brief Introduction:intermediates, drug discovery;Assay:99.1%.
Tel:86-25-83697070
Address:Rm.902 Longyin Plaza, No. 217 Zhongshan Rd.(N) Nanjing 210009,China

Supply company 3: Jintan Aite Bio-science & technology Co.,Ltd

Updatetime:Nov 06 2013
FOB Price:1 USD/Kilogram Purity:99%
Min. Order:200/Gram Supply Ability:20 Month/Kilogram
DetailDesc: Product:N-Boc-4-Hydroxypiperidine Cas No.:109384-19-2 Molecular formula:C 10 H 19 NO 3 Molecular weight:201.26 Purity:99% Melting:60-65C
Tel:86-519-82566282
Address:No. 296,Huacheng Road,Jintan,Jiangsu

Supply company 4: Shanghai Hobor Chemical Co..Ltd

Updatetime:Oct 11 2013
FOB Price:195 USD/Kilogram Purity:98.0%Min Min. Order:1/Kilogram Supply Ability:2000 Month/Kilogram
DetailDesc: Name n-boc-4-hydroxypiperidine Molecular Formula C10H19NO3 Molecular Weight 201.26 CAS Registry Number 109384-19-2 Melting point 60-65 C appearance:off-white to white powder Assay:98.0%Min If you need the MSDS & COA .
Tel:86-21-61026752
Address:Bldg 1,No. 268, XinJia Road,SongJiang District, Sh

Supply company 5: Wuxi Qianhao Biology CO.,Ltd

Updatetime:Dec 28 2012
Purity:>98% Min. Order:1/Gram Supply Ability:100 Month/Kilogram
DetailDesc: Fchemicals is one of the largest suppliers and manufacturers of various hi-tech fluorides, heterocyclic compounds, and chiral building blocks in China. Fchemicals is devoted to continual development of chemical technology, new materials, powerful reagents and raw chemicals. Supp…
Tel:86-510-86419776
Address:Room 1007,Jiangyin Life Science Incubator&Investor

Supply company 6: Hangzhou Bm Chemical Co.,Ltd

Updatetime:Dec 04 2012
Tel:86-571-82864080
Address:#170 XIAOSHAO,HANGZHOU
Introduction:Profile: Hangzhou BOMI Chemical Co.,Ltd. is a manufacturer, supplier and exporter of special ingredients, APIs & chemical intermediates. We deal with a range of chemical reactions and fermentations. Our product line includes amino acids, bioproducts, extracts and biochemicals.

Supply company 7: Trademax Pharmaceuticals & Chemicals Co., Ltd

N-Boc-4-piperidinol
Updatetime:Oct 24 2011
Tel:86-021-52387128
Address:728 Yan-an Road (West), Huamin Empire Plaza, Suite 7B,Shanghai 200050, China.
Introduction:Trademax will keep focusing on: Organic Fine Chemicals Pharmaceutical Intermediates Active Pharmaceutical Ingredients (API) Custom Synthesis Custom Manufacturing New Industrial Chemicals.

Supply company 8: Shanghai Dell Chemical Co.Ltd

N-BOC-4-Hydroxypiperidine
Updatetime:Dec 13 2013
Purity:NLT99% Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton
DetailDesc:Shanghai Dell Chemical Co.Ltd. is specialized in trading and developing active pharmaceutical ingredients, intermediates, API, and custom synthesis according to client’s requirements.
Tel:86-21-51950635
Address:Nianjiabang Rd, Pudong, Shanghai

Want to learn more supply information about N-BOC-4-Hydroxypiperidine, you can access the guidechem.com. Guidechem.com is just a place for you to look for chemicals what you need.