Malathion is a pesticide

Malathion is a man-made organophosphate insecticide that is commonly used to control mosquitoes and a variety of insects that attack fruits, vegetables, landscaping plants, and shrubs. It can also be found in other pesticide products used indoors and on pets to control ticks and insects, such as fleas and ants.

Malathion(CAS NO:121-75-5) is the active ingredient in mosquitocontrol products including Fyfanon and Atrapa. These products contain over 95% malathion and are often applied undiluted. However, they may be diluted with a petroleum solvent similar to kerosene before application, in which case petroleum solvent will make up most of the pesticide solution.

Because pesticide products are inherently toxic, no pesticide exposure is risk free. The likelihood of experiencing adverse health effects from exposure to any pesticide, including malathion, depends primarily on the amount of pesticide that a person contacts and the amount of time the person is in contact with that pesticide. In addition, a person’s age, sex, genetic makeup, life style and/ or general health characteristics can affect his or her likelihood of experiencing adverse health effects as a result of exposure to pesticides.

Malathion(CAS NO:121-75-5) is a pesticide that is widely used in agriculture, residential landscaping, public recreation areas, and in public health pest control programs such as mosquito eradication.In the US, it is the most commonly used organophosphate insecticide.

Malathion was used in the 1980s in California to combat the Mediterranean Fruit Fly. This was accomplished on a wide scale by the near weekly aerial spraying of suburban communities for a period of several months. Formations of three or four agricultural helicopters would overfly suburban portions of Alameda County, San Bernardino County, San Mateo County, Santa Clara County, San Joaquin County, Stanislaus County, and Merced County releasing a mixture of malathion and corn syrup, the corn syrup being a bait for the fruit flies. Malathion has also been used to combat the Mediterranean fruit fly in Australia.

Malathion was sprayed in many cities to combat West Nile virus. In the Fall of 1999 and the Spring of 2000, Long Island and the five boroughs of New York City were sprayed with several pesticides, one of which was malathion. While it was claimed by some anti-pesticide groups that use of these pesticides caused a lobster die-off in Long Island Sound, there is no conclusive evidence yet to support this.

Manitoba ordered the city of Winnipeg, Manitoba to be sprayed in July 2005 as part of the West Nile virus campaign. Prior to this, malathion was used over the last couple of decades on a regular basis during summer months to kill nuisance mosquitoes, but homeowners were allowed to exempt their properties if they chose. Today, Winnipeg is the only major city in Canada with an ongoing Malathion nuisance-adult-mosquito-control program.

Malathion is applied at very low concentrations to control mosquitoes.Malathion is unlikely that adverse health effects will occur as a result of this use for most people, but some individuals may experience health effects. For these reasons, individuals should consider taking steps to minimize their exposure to malathion if it is applied to control mosquitoes.

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Basic properties and Suppliers information of 2-fluoroaniline

Basic properties of 2-fluoroaniline:

Category : Intermediates
EC NO : 261-034-1
MF : C6H5ClFN
MW : 145.56
Appearance: clear to brown liquid
Solubility: slightly soluble
Synonyms : 2-fluoro-4-chloroaniline;4-Chloro-2-fluoroaniline
Stability: Stable under normal temperatures and pressures.
CAS NO : 348-54-9

Toxic if inhaled.Harmful if swallowed.Harmful in contact with skin.Causes skin irritation.Causes serious eye irritation.Flammable liquid and vapour.May cause damage to organs through prolonged or repeated exposure.

Keep away from heat/sparks/open flames/hot surfaces. No smoking. Use explosion-proof electrical/ventilating/lighting/ equipment. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

Suppliers information of 2-fluoroaniline(CAS NO:348-54-9):

Suppliers information 1:
2-Fluoroaniline
Updatetime:Sep 23 2013
Purity:98% Supply Ability:g/kg
DetailDesc:Atomax Chemicals Co.,Ltd a leading global supplier and manufacturer of chiral chemicals, amino acids, aromatic and pyridine halogens, natural extracts and pharmaceutical raw materials. we are a registered chemicals provider for most giant pharmaceutical company like Merck, Pfizer, Novartis, Roche, Astrazeneca, Sanofi-Aventis, etc.
Tel:86-755-33239182
Address:Huiji302 Hutingju Sanwei Xixiang SHENZHEN 518126, China

Suppliers information 2:
2-Fluoroaniline
Updatetime:Oct 16 2013
Tel:86-21-12345678
Address:Lane No.36, Zhongke road 2195, Zhangjiang high-tech park, Pudong new area Shanghai, China
Introduction:Founded by a group of veterans from the US biopharmaceutical industry in 2010, P&T is now a leading Shanghai-based CRO company providing drug discovery and development services worldwide. With our technical expertise and excellent research facilities, we offer broad and integrated chemical synthesis (custom synthesis, library design and synthesis), medicinal chemistry.

Suppliers information 3:
2-Fluoroaniline
Updatetime:Nov 18 2013
DetailDesc: Molecular formula : C6H6FN MW : 111.1185 CAS No. :348-54-9 nature : light yellow transparent liquid, the temperature -29 C, the boiling point of 183 C, flash point of 66 C and relative density of 1.151, RI 1.5420
Tel:86-27-83229541
Address:Add: Room 303, Chuangye Building, Qixiong Rd., Wujiashan, Dongxihu District. WUHAN CHINA

Suppliers information 4:
2-Fluoroaniline
Updatetime:Jan 22 2013
Tel:+86-(21)-6427-9170
Address:Suite 22G, Shanghai Industrial Investment Bldg, 18 Caoxi Road, Shanghai 200030,
Introduction: Profile: Shanghai Freemen Chemicals Co., Ltd. offers agrochemical ingredients, food additives, water treatment chemicals, flavours,fragrances and intermediates. Water treatment chemicals include 2,2-dibromo-3-nitriloproptioamide, 1-bromo-3-chloro-5,5-dimethylhydantoin, benzyl triethyl ammonium chloride, glutaraldehyde and alkyl dimethyl ethylbenzyl ammonium chloride.

Suppliers information 5:
2-Fluoroaniline
Updatetime:Dec 04 2012
Tel:+86-(21)-52702636
Address:No.3 ,Lane 1273, Tong Pu Road, Shanghai 200333,
Introduction:Profile: Chemspec International Limited is a contract manufacturer of highly engineered specialty chemicals. We are specialized in manufacturing fluorinated specialty chemicals. Our specialty chemicals, typically highly engineered chemicals, are used as building blocks for more advanced chemicals or used to enhance the performance of the end products of our clients.

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What benefit can we get from Isoflavones

Isoflavones comprise a class of organic compounds, often naturally occurring, related to the isoflavonoids. Many act as phytoestrogens in mammals. Some are termed antioxidants because of their ability to trap singlet oxygen.

Some isoflavones(CAS NO:574-12-9), in particular soy isoflavones, when studied in populations eating soy protein, have indicated that there is a lower incidence of breast cancer and other common cancers because of its role in influencing sex hormone metabolism and biological activity through intracellular enzymes, protein synthesis, growth factor actions, malignant cell proliferations, differentation and angiogenesis.

They are acting as phytoestrogens that are thought of by some as useful in treating cancer.They are also very strong antioxidants.Critics of the inclusion of isoflavones in food claim that they increase the incidence of epithelial hyperplasia, which precedes cancerous tumors, and that they cause goitre and hyperthyroidism.Phytoestrogens may actually promote cancer.

Isoflavones(CAS NO:574-12-9) are produced from a branch of the general phenylpropanoid pathway that produces all flavonoid compounds in higher plants. Soybeans are the most common source of isoflavones and the major isoflavones in soybean are genistein and daidzein.

Research in several areas of healthcare has shown that consumption of isoflavones may play a role in lowering risk for disease. They can fight disease on several fronts. The following potential health benefits are attributed to isoflavones:

Reduce cancer risk
Isoflavones seem to be protect agains tumors because they act against cancer cells in a way similar to many common cancer-treating drugs. Population-based studies show a strong association between consumption of isoflavones and a reduced risk of breast and endometrial cancer. Women who ate the most soy products and other foods rich in isoflavones reduced their risk of endometrial cancer by 54%.

Protect against prostate problems
Isoflavones may be benificial for men’s health because they may protect against enlargement of the male prostate gland. Studies show isoflavones slowed prostate cancer growth and caused prostate cancer cells to die. Isoflavones act against cancer cells in a way similar to many common cancer-treating drugs.

Reduce heart disease risk
Soy isoflavones also appear to reduce cardiovascular disease risk via several distinct mechanisms. Isoflavones inhibit the growth of cells that form artery clogging plaque. These arteries usually form blood clots which can lead to a heart attack. A review of 38 controlled studies on soy and heart disease concluded that soy is definitely effective for improving cholesterol profile. There is some evidence that isoflavones are the active ingredients in soy responsible for improving cholesterol profile.

Isoflavones improve bone health
Soy Isoflavones help in the preservation of the bone substance and fight osteoporosis. This is the reason why people in China and Japan very rarely have osteoporosis, despite their low consumption of dairy products, whereas in Europe and North America the contrary happens. Unlike estrogen, which helps prevent the destruction of bone, evidence suggests that isoflavones may also assist in creating new bone. Other studies are not entirely consistent, but evidence suggests that genistein and other soy isoflavones can help prevent osteoporosis.

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Buying N-BOC-4-Hydroxypiperidine in guidechem

 

Empirical Formula: C10H19NO3
Molecular Weight: 201.2628
IUPAC Name: tert-butyl 4-hydroxypiperidine-1-carboxylate
Appearance: White to cream powder
storage temp. Store at -15 C
Nominal Mass: 201 Da
Average Mass: 201.2628 Da
Monoisotopic Mass: 201.136493 Da
Index of Refraction: 1.495
Molar Refractivity: 53.03 cm3
Molar Volume: 181.6 cm3
Surface Tension: 42.5
Density: 1.107 g/cm3
Flash Point: 130.6 C
Enthalpy of Vaporization: 61.7 kJ/mol
Boiling Point: 292.3 C at 760 mmHg
CAS NO.: 109384-19-2
Usages:N-BOC-4-Hydroxypiperidine is used as pharmaceutical intermediate
Product Categories: Alcohols and Derivatives;Amines and Anilines;pharmacetical;Pyrans, Piperidines &Piperazines;Piperidine;Heterocyclic Compounds;Piperidines;Pyrans, Piperidines & Piperazines

After introducting the basic properties of N-BOC-4-Hydroxypiperidine, I will show you some suppliers information about this chemical on Guidechem, if you need to buy some N-BOC-4-Hydroxypiperidine, you can access to Guidechem, and contact them. I hope this information is useful for you.

Supplier one
N-BOC-4-Hydroxypiperidin(CAS NO:109384-19-2)
Updatetime:Nov 25 2013
Purity:98.00% Min. Order:10/Gram Supply Ability:560 Month/Kilogram
DetailDesc: Appearance: white or off-white crystalline powder Molecular Weight: 201.26 Density: 1.107 g/cm3 Boiling Point: 292.3 oC at 760 mmHg Melting Point: 60-65℃ Flash Point: 130.6 oC Storage Temperature: Store at -15°C Refractive index: 1.495
Tel:86-27-88660577
Address:27th FL.shuian international masion Bldg.1,Heping Ave.wuhan city

Supplier two
N-BOC-4-Hydroxypiperidin
Updatetime:Nov 25 2013
Min. Order:1/Gram Supply Ability:10 Month/Metric Ton
DetailDesc:tert-butyl 4-hydroxypiperidine-1-carboxylate
Tel:86-571-85232161
Address:6th Floor, Block C, 7th Building, Xigang Xinjie, Xihu Industrial Park, Sandun Town, Hangzhou, China.

Supplier three
N-BOC-4-Hydroxypiperidin
Updatetime:Sep 23 2013
Purity:95%min Min. Order:mg/g/Gram Supply Ability:g/kg Month/Kilogram
DetailDesc:We are a leading global supplier and manufacturer of chiral chemicals, amino acids, aromatic and pyridine halogens, natural extracts and pharmaceutical raw materials. Those chemicals are widely used in the pharmaceutical and fine chemical industries and in research laboratories.
Tel:86-755-33239182
Address:Huiji302 Hutingju Sanwei Xixiang SHENZHEN 518126, China

Supplier four
N-BOC-4-Hydroxypiperidin
Updatetime:Nov 25 2013
Purity:99 Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton
DetailDesc:1,1-Dimethylethyl4-hydroxypiperidine-1-carboxylate;1-(tert-Butoxycarbonyl)-4-hydroxypiperidine;1-(tert-Butyloxycarbonyl)piperidin-4-ol;1-Boc-4-hydroxypiperidine;1-Boc-piperidin-4-ol;1-tert-Butoxycarbonyl-4-piperidinol;1-tert-Butyloxycarbonyl-4-hydroxypiperidine;4-Hydroxy-1-(tert-…
Tel:0086-531-58773055
Address:No.59 Gongye South RD

Supplier five
N-BOC-4-Hydroxypiperidin
Updatetime:Oct 16 2013
Tel:86-21-12345678
Address:Lane No.36, Zhongke road 2195, Zhangjiang high-tech park, Pudong new area Shanghai, China
Introduction:Founded by a group of veterans from the US biopharmaceutical industry in 2010, P&T is now a leading Shanghai-based CRO company providing drug discovery and development services worldwide. With our technical expertise and excellent research facilities, we offer broad and integrated chemical synthesis (custom synthesis, library design and synthesis), medicinal chemistry (hit generation, lead opt…

Supplier six
N-BOC-4-Hydroxypiperidin
Updatetime:Nov 25 2013
Tel:86-311-89830448
Address:Room 37-2-2501, Yiyuan Dong Gang Jianshe Nan Stree
Introduction:Shijiazhuang Sdyano Fine Chemical Co., Ltd. is a company specializing in pharmaceutical intermediates, liquid crystal intermediates, PDLC LCD, OLED LCD, such as fine chemicals R & D, production and sales of integrated chemical enterprise modernization. Our company has three subsidiaries: R & D center, production base and sales. The production quantity can be done from the number of grams…

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What are the usags of Thiophene-2-ethylamine?

Thiophene-2-ethylamine, also known as Thiofuran, is a cyclic compound containing four carbon atoms and one sulphur atom in a ring. It is a toxic, flammable, highly reactive, colorless liquid insoluble in water (soluble in alcohol and ether) and melts at -38 C, boils at 84 C. It is used as a solvent and chemical intermediate. Its derivatives are widely used in manufacturing dyes, aroma compounds and pharmaceuticals. They are used as monomers to make condensation copolymers.

The other properties of Thiophene-2-ethylamine are:
IUPAC Name: 2-thiophen-2-ylethanamine
Formula: C6H9NS
MOL WT: 127.20
PHYSICAL STATE: clear to yellow liquid
SOLVENT SOLUBILITY: slightly soluble
STABILITY: Stable under ordinary conditions
CAS NO. : 30433-91-1

Thiophene-2-ethylamine is an analog to furan and pyrrole where the sulfur atom is replaced by O and NH respectively. It is a toxic, flammable, and colorless liquid; insoluble in water (soluble in most organic solvents including alcohol and ether); melting at -38 C, boiling at 84 C.

Thiophene-2-ethylamine(CAS NO:30433-91-1) is lipid-lowering drugs, platelet aggregation inhibitors, cardiovascular vasodilators, 5 – lipoxygenase inhibitors and a variety of antimicrobial drugs and other biologically active drug intermediates, mainly used for the synthesis of cardiovascular and cerebrovascular disease drugs ticlopidine hydrochloride. As downstream drug development, the Thiophene-2-ethylamineis paid more attention to the fine chemical intermediates.

It is the simplest aromatic compound containing sulfur atom and it shares some similar chemical properties with benzene. The lone electron pairs on sulfur in the delocalized pi electron system does not exhibits the properties of thioethers but aromaticity. The sulfur atom is unreactive but the adjacent carbons are susceptible to attack by electrophiles. It is reactive toward sulfonation.

In commercial Thiophene-2-ethylamine can be prepared by the reaction of butane and sulfur. Thiophenes are also prepared by the reaction of diketones with Lawesson’s reagent. This compoud and its derivatives exist in petroleum or coal. It derivatives are also found in natural plant pigments. Biotin, a water-soluble B-complex vitamin, is a reduced thiophene derivative. Thiophene moiety is found in ccphalothin antiboitics.

Thiophene-2-ethylamine is used as a solvent and chemical intermediate. Its derivatives are used in manufacturing dyes, aroma compounds and pharmaceuticals. They are used as monomers to make condensation copolymers. Organic conductive polymers are responsible for the important materials science for the application of polymer electro luminescence.

Thiophene-2-ethylamine is used as an intermediate to manufacture pharmaceuticals such as antiplatelet drug (Clopidogrel, Ticlopidine) used to lessen the chance of heart attack or stroke.

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How to take ferrous fumarate oral?

Ferrous fumarate, also known as Iron(II) fumarate, is the iron(II) salt of fumaric acid, occurring as a reddish-orange powder, used to supplement iron intake. It has the chemical formula C4H2FeO4. Pure ferrous fumarate has an iron content of 32.87%, therefore one tablet of 300 mg iron fumarate will contain 98.6 mg of iron (548% Daily Value based on 18 mg RDI). The CAS NO is 141-01-5.

Ferrous fumarate is a type of iron. You normally get iron from the foods you eat. In your body, iron becomes a part of your hemoglobin (HEEM o glo bin) and myoglobin (MY o glo bin). Hemoglobin carries oxygen through your blood to tissues and organs. Myoglobin helps your muscle cells store oxygen.

Ferrous fumarate(CAS NO:141-01-5) is used to treat iron deficiency anemia (a lack of red blood cells caused by having too little iron in the body). Ferrous fumarate may also be used for purposes other than those listed in this medication guide.

So,how to use ferrous fumarate oral, is there something should be careful?

1.Follow all directions on the product package, or take as directed by your doctor. Do not take more than the recommended dosage. If you are uncertain about any of the information, consult your doctor or pharmacist.

2.Ferrous fumarate oral is best taken on an empty stomach 1 hour before or 2 hours after meals. Take with a full glass of water (8 ounces or 240 milliliters) unless your doctor directs you otherwise. If stomach upset occurs, you may take this medication with food. Avoid taking antacids, dairy products, tea, or coffee within 2 hours before or after this medication because they will decrease its effectiveness. Do not lie down for 10 minutes after taking this medication.

3.Swallow extended-release capsules whole. Do not crush or chew extended-release capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

4. If you are taking chewable tablets, chew the medication thoroughly, then swallow.

5.If you have a liquid form, carefully measure out your dose using a medication-measuring device, mix ferrous fumarate oral in a glass of water or juice, and drink the mixture through a straw to prevent staining the teeth. If your liquid form is to be given by dropper, the dose may be placed well back on the tongue and followed with water or juice. If your liquid form is a suspension, shake the bottle well before each dose.

Take ferrous fumarate oral regularly in order to get the most benefit from it. To help you remember, take ferrous fumarate oral at the same time(s) each day.

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Application of 4-Bromotoluene

4-Bromotoluene has the Synonyms of 1-Brom-4-methylbenzol; 1-bromo-4-methyl-benzen; 1-Methyl-4-bromobenzene;4-Bromo-1-methybezene;4-bromo-toluen;4-Bromtoluol;4-Methylbromobenzene; 1-Bromo-4-methylbenzene; 4-Tolyl bromide; 4-Methylbromobenzene; p-Methylphenyl bromide. With the CAS NO.106-38-7, it has the Molecular Formula of C7H7Br and the Molecular Weight of 171.03448. It is producted by diazotizing and swapping paratoluidine.It is used in the field of organic synthesis.

Application of 4-Bromotoluene(CAS NO:106-38-7):

When substituted benzene molecules undergo electrophilic substitution reactions, substituents on a benzene ring can influence the reactivity. Activating substituents that activate the benzene ring toward electrophilic attack can alter the reaction rate or products by electronically or sterically affecting the interaction of the two reactants. deactivating substituents removes electron density from the benzene ring, making electrophilic aromatic substitution reactions slower and more difficult than benzene itself.

For example, a hydroxy or methoxy substituent in phenol and anisole increases the rate of electrophilic substitution, while a nitro substituent decreases the ring’s reactivity. Electron donating substituents activate the benzene ring toward electrophilic attack, and electron withdrawing substituents deactivate the ring, making it less reactive to electrophilic attack. The strongest activating substituents are the amino (-NH2) and hydroxyl (-OH) groups.

Toluene, aniline and phenol are activated aromatic compounds. Examples of deactivated aromatic compounds are nitrobenzene, benzaldehyde and halogenated benzenes.

Activating substituents generally direct substitution to the ortho and para positions where substitutions must take place. With some exceptions, deactivating substituents direct to the meta position. Deactivating substituents which orient ortho and para- positions are the halogens (-F, -Cl, -Br, -I) and -CH2Cl, and -CH=CHNO2

When disubstituted benzene molecules undergo electrophilic substitution reactions, a new substituent is directed depends on the orientation of the existing substituents and their individual effects; whether the groups have cooperative or antagonistic directing effects. Ortho position is the most reactive towards electrophile due to the highest electron density ortho positions. But this increased reactivity is countervailed by steric hindrance between substituent and electrophile.

A nucleophilic substitution is a substitution reaction which the nucleophile displaces a good leaving group, such as a halide on an aromatic ring. This mechanism is called SNAr ( the two-step addition-elimination mechanism), where electron withdrawing substituents activate the ring towards nucleophilic attack. Addition-elimination reactions usually occur at sp2 or sp hybridized carbon atoms, in contrast to SN1 and SN2 at sp3. Chloro and bromobenzene reacts with the very strong base sodium amide (NaNH2) to give good yields of aniline. Other nucleophilic aromatic substitution mechanisms include benzyne mechanism and free radical (SRN1) mechanism.

Common reactions of substituent groups on benzene ring include:

1.Conversion of halogens into other various substituents
2.Modifying activating substituents
3.Oxidative degradation of alkyl chain
4.Reduction of nitro or carbonyl substituents
5.Reversibility of the aromatic sulfonation reaction
6.4-Bromotoluene is used in manufacturing pharmaceuticals (especially for antihypertensive like losartan, Irbesartan ), pesticides and other organic compounds.

When you are using this chemical, please be cautious about it as the following:

1. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;
2. Avoid release to the environment. Refer to special instructions safety data sheet;
3.After contact with skin, wash immediately with plenty of … (to be specified by the manufacturer);
4. Wear suitable gloves and eye/face protection;

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Azamethiphos extend to fin fish

Azamethiphos is an organothiophosphate insecticide. It is a veterinary drug used in Atlantic salmon fish farming to control parasites.

On 23 May 2012 the European Commission adopted a Regulation1 establishing maximum residue limits for azamethiphos in fin fish, valid throughout the European Union. These maximum residue limits were based on the favourable opinion and the assessment report adopted by the Committee for Medicinal Products for Veterinary Use.

Azamethiphos(CAS NO:35575-96-3) is intended for use in fish farming to control external parasites with an application rate of 0.1 to 0.2 mg/litre as a bath treatment. Fish Vet Group Ltd submitted the application for the extension of maximum residue limits to the European Medicines Agency, on 26 January 2011.

Based on the available data, the Committee for Medicinal Products for Veterinary Use recommended on 15 September 2012 the establishment of maximum residue limits for azamethiphos in fin fish. Subsequently the Commission recommended on 14 March 2012 that maximum residue limits in fin fish are established. This recommendation was confirmed on 4 April 2012 by the Standing Committee on Veterinary Medicinal Products and adopted by the European Commission on 23 May 2012.

Azamethiphos(CAS NO:35575-96-3) is an organophosphorus insecticide which acts by inhibition of cholinesterase activity. In Atlantic salmon azamethiphos is used in fish farming to control external parasites with an application rate of 0.1 to 0.2 mg/litre as a bath treatment.

Azamethiphos was previously used as a pesticidal spray for control of flies and cockroaches in warehouses and other buildings, but the authorisation was withdrawn by Commission Regulation (EC) No. 2076/2002 of 20 November 2002. It was previously assessed by the CVMP and a pharmacological ADI of 0.025 mg/kg bw, i.e. 1.5 mg/person was established.

Fish Vet Group Limited submitted the application for the extension of maximum residue limits for azamethiphos from Salmonidae to fin fish to the European Medicines Agency on 21 February 2011. Azamethiphos is intended for use in fin fish (e.g. sea bass, sea bream, coy and tilapia) for the treatment of external parasites with an intended application rate for this use of 0.1 to 0.2 mg/litre as a bath treatment.

Azamethiphos was previously assessed by the CVMP and a pharmacological ADI of 0.025 mg/kg bw, i.e. 1.5 mg/person was established based on the NOEL of 2.5 mg/kg bw/day from a dog study (brain cholinesterase activity) and applying a safety factor of 100. Therefore, no further assessment regarding the consumer safety of the substance is required for the purpose of this extension application. 

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Safe storage of L-Alaninol

 

IUPAC Name: 2-aminopropan-1-ol
Molecular formula: C3H9NO2
Molecular weight: 75.11
Physical state: viscose liquid
Appearance: clear and colorless
Boiling range: 173-176 C (760mmHg )
Flash Point: 83.9 C
Density: 0.9650g/cm3
Enthalpy of Vaporization: 47.83 kJ/mol
Vapour Pressure: 0.373 mmHg at 25 C
Storage temp: 2-8 C
Sensitive: Hygroscopic
CAS NO: 2749-11-3

Stability and activity

Chemical stability: stable in room temp. and under atmospheric pressure; its color will change with exposure to the air.
Conditions avoided: incompatible raw material、fire source, insolation, overheated
Restrained substances: air, oxidant, acids.
Harmful dissociation product: NO2,CO,CO2,N2,irritative fog and gas.

First aid measures about L-Alaninol(CAS NO.2749-11-3):

Eyes:Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed. Extensive irrigation with water is required (at least 30 minutes).

Skin:Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.

Ingestion:Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.

Inhalation:Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.

Handing and storage about L-Alaninol:

Handling: Wash thoroughly after handling. Use only in a well-ventilated area.Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame. Do not get on skin or in eyes. Do not ingest or inhale. Handle under an inert atmosphere. Store protected from air. Discard contaminated shoes. Do not pressurize, cut, weld, braze,solder, drill, grind, or expose empty containers to heat, sparks or open flames.

Storage: Keep L-Alaninol away from heat, sparks, and flame. Keep L-Alaninol away from sources of ignition. Keep container closed when not in use. Store L-Alaninol in a tightly closed container. Store it in a cool, dry, well-ventilated area away from incompatible substances. Corrosives area. Do not expose to air.Store under an inert atmosphere.

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D(+)-Malic acid in food

D(+)-Malic acid is an organic compound with the formula HO2CCH2CHOHCO2H. It is a dicarboxylic acid that is made by all living organisms, contributes to the pleasantly sour taste of fruits, and is used as a food additive.

D(+)-Malic acid(CAS NO:636-61-3) has two stereoisomeric forms (L- and D-enantiomers), though only the L-isomer exists naturally. The salts and esters of D(+)-Malic acid are known as malates. The malate anion is an intermediate in the citric acid cycle.

The only difference between the two is that they rotate the light shining on them in two different directions. L-Malic acid is produced naturally in fruits. 90% of the acid in apples is D(+)-Malic acid(CAS NO:636-61-3). When D(+)-Malic acid is produced synthetically, a mixture of the two isomers is obtained which is called DL-Malic acid (because it contains both D- and L-Malic acid). When you eat DL-Malic acid, your body digests it in just the same way as it does for L-Malic acid. It is part of the Krebs cycle.

D(+)-Malic acid was first isolated from apple juice by Carl Wilhelm Scheele in 1785. Antoine Lavoisier in 1787 proposed the name acide malique which is derived from the Latin word for apple, mālum. It contributes to the sourness of green apples. It is present in grapes and in most wines with concentrations sometimes as high as 5 g/l. It confers a tart taste to wine, although the amount decreases with increasing fruit ripeness. The taste of this chemical is very clear and pure in rhubarb, a plant for which it is the primary flavor.

The process of malolactic fermentation converts D(+)-Malic acid to much milder lactic acid. It occurs naturally in all fruits and many vegetables, and is generated in fruit metabolism.

D(+)-Malic acid, when added to food products, is denoted by E number E296. It is the source of extreme tartness in USA-produced confectionery, the so-called extreme candy. It is also used with or in place of the less sour citric acid in sour sweets. These sweets are sometimes labeled with a warning stating that excessive consumption can cause irritation of the mouth. It is approved for use as a food additive in the EU, USA and Australia and New Zealand (where it is listed by its INS number 296).

The addition of D(+)-Malic acid to fruit juice, to increase the acid content for example, is strictly illega l, although the EC permits its addition to wine. The naturally occurring form of D(+)-Malic acid in fruits is the L-enantioner. Synthetically produced this chemical consis ts of the racemic D/L mixture. The much higher cost of the L-enantiomer, which is currently 20 times that of the D/L mixture,discourages its use as an adulterant. Therefore, the measurement of D(+)-Malic acid alone is sufficient to detect the illegal addition of synthetic Malic acid. A sample of orange juice sampled during 1991 and analysed also by the L eatherhead Food RA contained 103 ppm of D(+)-Malic acid (authentic orange juice should not contain any).

D(+)-Malic acid can be measured spectrophotometrically using the enzymatic method, recently developed by Beutler and Wurst, available also as a test kit from Boehringer Mannheim GmbH.

A survey carried out by the Ministry of Agriculture Fisheries and Food in the U.K. in January 1991, co mpared methods for detection of added substances in leading brands of or ange juice, of 17 samples analysed, 10 contained D(+)-Malic acid , as a consequence of adulteration.

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